You are here

Introduction

George P. Chrousos, Distiguished Visiting Professor, KSU

George P. Chrousos is Professor and Chairman of the First Department of Pediatrics at the University of Athens School of Medicine, Athens, Greece, and former Chief of the Pediatric and Reproductive Endocrinology Branch of the National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland. He holds the UNESCO Chair on Adolescent Health Care since 2010. Prof. Chrousos is internationally recognized for his research on the glucocorticoid signaling system of the cell, on the diseases of the hypothalamic-pituitary-adrenal axis, and on the physiological and molecular mechanisms of stress. His contributions span a range of medical disciplines, including Medicine, Pediatrics, Endocrinology, Psychiatry, Rheumatology, Allergy, Surgery, Oncology and Reproductive Medicine.

Dr. Chrousos has written over 600 original scientific papers and his work has been cited in more than 50,000 other scientific articles, an irrefutable testimony to the importance and influence of his research. He is one of the most cited scientists internationally (ISI highly cited) both in Clinical Medicine and in Biology and Biochemistry and the highest cited clinical endocrinologist and pediatrician in the world. Dr. Chrousos has received numerous national and international awards. He was inducted as a master of both the American College of Endocrinology and the American College of Physicians. He is president of the European Society of Clinical Investigation. He is an elected member of the Institute of Medicine, The National Academies, Washington, DC, USA and the Academia Europaea, London, UK.

Professor Dr. George Chrousos visited Research Laboratory for vital signs and deliver a lecture entitled Nearoendocrinology of Stress and Metabolic Syndromes.

Activities

Professor Dr. George Chrousos visited Research Laboratory for vital signs and deliver a lecture entitled Nearoendocrinology of Stress and Metabolic Syndromes.

Apointments and Affiliations

   Professor and Chairman, First Department of Pediatrics,

Athens University Medical School, Children’s Hospital Aghia Sophia, Athens, Greece

Director, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics

Athens University Medical School, Children’s Hospital Aghia Sophia, Athens, Greece

Clinical Professor of Pediatrics, Georgetown University Medical School, Washington, D.C.

Adjunct Professor of Physiology and Biophysics, Georgetown University Medical School, Washington, D.C.

Director, Division of Endocrinology, Metabolism and Diabetes, Evgenidion Hospital,

Athens University Medical School, Athens, Greece

Senior Scientist and Director, Center for Clinical Research, Foundation for Biomedical Research Foundation of the Academy of Athens (IIBEAA), Athens, Greece

Distinguished Visiting Scientist, NICHD, NIH, Bethesda, MD, USA

Vice President, National Council on Research and Technology, Ministry of Education, Greece

UNESCO Chair on Adolescent Health Care, Athens, Greece.

Research Interests
Neuroendocrinology, Neuroimmunology, Pediatric Endocrinology, Adrenal disorders, Hypothalamic-pituitary adrenal axis, Stress, Glucocorticoids, Human development

Publications

ORIGINAL
Chrousos G.P., Renquist D., Brandon D., Eil C., Pugeat M., Vigersky R., Cutler G.B., Loriaux D.L., Lipsett M.B. (1982) Glucocorticoid Resistance and Primate Evolution: Receptor-mediated Mechanisms. Proc. Natl. Acad. Sci. 179: 2036-2040.
Chrousos G.P., Vingerhoeds A., Brandon D., Pugeat M., Eil C., Loriaux D.L., Lipsett M.B. (1982) Primary Cortisol Resistance in Man: A Glucocorticoid Receptor-mediated Disease. J. Clin. Invest. 69: 1261-1269.
Chrousos G.P., Schulte H.M., Oldfield E.H., Gold P.W., Cutler G.B. Jr., Loriaux D.L. (1984) The Corticotropin Releasing Factor Stimulation Test: An Aid in the Differential Diagnosis of Cushing’s Syndrome. N. Engl. J. Med. 310: 622-627.
Gold P.W., Gwirtzman H., Avgerinos P., Nieman L.K., Gallucci W.T., Kaye W., Jimerson D., Ebert M., Rittmaster R., Loriaux D.L.,Chrousos G.P. (1986) Abnormal Hypothalamic-pituitary-Adrenal Function in Anorexia Nervosa: Pathophysiologic Mechanisms in Underweight and Weight-corrected Patients. N. Engl. J. Med. 314: 1335-42.
Udelsman R., Gallucci W.T., Ramp J., Goldstein D.S., Lipford R., Norton J.A., Loriaux D.L., Chrousos G.P. (1986) Adaptation during Surgical Stress: A Reevaluation of the Role of Glucocorticoids. J. Clin. Invest. 77: 1377-1381.
Luger A., Deuster P., Kyle S.B., Gallucci W.T., Montgomery L.C., Gold P.W., Loriaux D.L., Chrousos G.P. (1987) Acute Hypothalamic-pituitary-adrenal Responses to the Stress of Treadmill Exercise: Physiologic Adaptations to Physical Training. N. Engl. J. Med. 316: 1309-1315.
Calogero A., Gallucci W.T., Gold P.W., Chrousos G.P. (1988) Multiple Regulatory Feedback Loops on Hypothalamic Corticotropin Releasing Hormone Secretion. J. Clin. Invest. 82: 767-774.
Hurley D., Accilli D., Stratakis C., Karl M., Vamvakopoulos N., Rorer E., Constantine K., Taylor S., Chrousos G.P. (1991) Mutation of the Glucocorticoid Receptor Gene in Familial Glucocortcoid Resistance. J Clin Invest 87:680-686.
Karalis C., Sano H., Redwine J., Listwak S., Wilder R., Chrousos G.P. (1991) Autocrine or Paracrine Inflammatory Actions of Corticotropin Releasing Hormone In Vivo. Science 254:421-423.
Vamvakopoulos N.C., Chrousos G.P. (1993) Evidence of Direct Estrogen Regulation of Human Corticotropin Releasing Hormone Gene Expression: Potential Implications for the Sexual Dimorphism of the Stress Response and Immune/Inflammatory Reaction. J. Clin. Invest. 92:1896-1902.
Tsigos C., Arai K., Hung W., Chrousos G.P. (1993) Hereditary Isolated Glucocorticoid Deficiency is Associated with Abnormalilties of the Adrenocorticotropin Receptor Gene. J. Clin. Invest. 92:2458-2461.
Magiakou M.A., Mastorakos G., Oldfield E.H., Gomez M.T., Doppman J.L., Cutler G.B. Jr., Nieman L.K., Chrousos G.P. (1994) Cushing Syndrome in Children and Adolescents: Presentation, Diagnosis and Therapy. N. Engl. J. Med. 331:629-36.
Bamberger C.M., Bamberger A.M., De Castro M., Chrousos G.P. (1995) Glucocorticoid Receptor- Beta, a Potential Endogenous Inhibitor of Glucocorticoid Action in Humans. J. Clin. Invest. 95:2435-2441.
Webster E.L., Lewis D.B., Torpy D.J., Zachman E.K., Rice K.C., Chrousos G.P. (1996) In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation. Endocrinology 137:5747-5750.
Vgontzas A.N., Papanicolaou D.A., Bixler E.O., Kales A., Tyson K., Chrousos G.P. (1997) Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity. J. Clin. Endocrinol. Metab. 82:1313-1316.
Kino T., Gragerov A., Kopp J.B., Stauber R.H., Pavlakis G.N., Chrousos, G.P. (1999) The HIV-1 Virion-associated Protein Vpr is a Coactivator of the Human Glucocorticoid Receptor. J. Exp. Med. 89:51-61.
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Lotsikas, A., Zachman, K., Kales, A., Prolo, P., Wong, M., Licinio, J., Gold, P. W., Hermida, R. C., Mastorakos, G., Chrousos G.P., (1999) Circadian Interleukin-6 Secretion and Quality and Depth of Sleep. J. Clinical Endocrinology & Metabolism, 84:2603-2607.
Vgontzas A Bixler E.O., Lin H.-M., Prolo P., Mastorakos G., Vela-Bueno A., Kales A., Chrousos G.P. (2001) Chronic Insomnia is Associated with Nyctohemeral Activation of the Hypothalamic-pituitary-adrenal Axis. J. Clin. Endocrinol. Metab.86: 3787-3794
Makrigiannakis A., Zoumakis E., Kalantaridou S., Coutifaris C., Coukos, G., Rice K., Gravanis, A. and Chrousos GP. (2001) Corticotropin-releasing Hormone (CRH) Promotes Blastocyst Implantation and Early Maternal Tolerance. Nature Immunology 2:1018-24
Charmandari E, Kino T, Souvatzoglou E, Vottero A, Bhattacharayya N, and Chrousos GP (2004) Natural Glucocorticoid Receptor Mutants Causing Glucocorticoid Resistance: Molecular Genotype, Genetic Transmission and Clinical Phenotype. J. Clin. Endocrinol. Metab. 89: 1939-1949.
Kino T, TiulpakovA, IchijoT, Chheng L, KozasaT and. ChrousosGP (2005) The GTP-binding (G) Protein bInteracts with the Activated Glucocorticoid Receptor and Suppresses Its Transcriptional Activity in the Nucleus. J Cell Biol 20;169(6):885-96.
Kino T, Ichijo T, Amin ND, Kesavapany S, Amin ND, Wang Y, Kim N, Player A, Garabedian MJ, Kawasaki E, Pant HC andChrousos G (2007) Cyclin-dependent Kinase 5 Differentially Regulates the Transcriptional Activity of the Glucocorticoid Receptor through Phosphorylation: Clinical Implications for the Nervous System Response to Glucocorticoids and Stress. Mol Endocrinol. 21:1552-1562
Pervanidou P, KolaitisG, CharitakiS, Lazaropoulou Ch, Papassotiriou I, Hindmarsh P,Bakoula Ch, Tsiantis Jand Chrousos GP(2007) The Natural History of Neuroendocrine Changes in Pediatric Post-traumatic Stress Disorder (PTSD) after Motor Vehicle Accidents: Progressive Divergence of Noradrenaline and Cortisol Concentrations over Time. Biol Psychiatry 62(10): 1095-102
Sakka SD, Loutradis D, Kanaka-Gantenbein C, Margeli A, Papastamataki M, Papassotiriou I, Chrousos GP (2009) Absence of Insulin Resistance and Low-grade Inflammation Despite Early Metabolic Syndrome Manifestations in Children Born after in Vitro Fertilization.Fertil Steril. 2010 Oct;94(5):1693-9.
KinoT, HurtDE, IchijoT, NaderN and ChrousosGP (2010) Noncoding RNA Gas5 is a Growth Arrest and Starvation-associated Repressor for the Glucocorticoid Receptor. Science Signaling 2010 Feb 2;3(107):ra8
COMPLETE REVIEWS
Chrousos G.P., Schuermeyer T., Oldfield E., Doppman J., Schulte H.M. Gold P.W., Loriaux D.L. (1985) The Clinical Applications of Corticotropin-Releasing Factor. Ann. Int. Med. 102: 344-358.
Gold P.W., Goodwin F., Chrousos, G.P. (1988) Clinical and Biochemical Manifestations of Depression: Relationship to the Neurobiology of Stress. (Part I and Part 2) N. Engl. J. Med. 319: 348-353 and 319: 413-420            
Chrousos G.P., Gold P.W. (1992). The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis. JAMA 267:1244-1252.
Chrousos G.P., Detera-Wadleigh S., Karl M. (1993) Syndromes of Glucocorticoid Resistance. Ann. Int. Med., 119:1113-1124.
Chrousos G.P.(1995) The Hypothalamic-Pituitary-Adrenal Axis and Immune-Mediated Inflammation. N. Engl. J. Med. 332:1351-1362.
Papanicolaou D.A., Wilder R.L., Manolagas S.C., Chrousos G.P. (1998) The Pathophysiologic Roles of Interleukin-6 in Human Disease. Ann. Intern. Med. 128:127-137.
Chrousos G.P.(1998) Stressors, Stress and Neuroendocrine Integration of the Adaptive Response: 1997 Hans Selye Memorial Lecture. Ann. NY Acad. Sci. 851:311-335.
Chrousos G.P., Torpy D., Gold P.W. (1998) Interactions Between the Hypothalamic-Pituitary- Adrenal Axis and the Female Reproductive System: Clinical Implications. Ann. Intern. Med.129:229-240.
Elenkov, I.J., Chrousos, G.P. (1999) Stress Hormones, Th1/Th2-patterns, Pro/Anti- Inflammatory Cytokines and Susceptibility to Disease. Trends Endo Metab., 10:359-368
Bornstein S.R., Stratakis C.A., Chrousos G.P. (1999) Adrenocortical Tumors: Recent Advances in Basic Concepts and Clinical Management. Ann. Intern. Med. 130:759-771
Chrousos G. P., (2000) The Stress Response and Immune Function: Clinical Implications, The 1999 Novera H. Spector Lecture. Ann. New York Acad. Sci., 917:38-67.
Koch C, Pacak K, Chrousos GP (2002) The Molecular Pathogenesis of Hereditary and Sporadic Adrenocortical and Adrenomedullary Tumors. J Clin Endocrinol Metab, 87: 5367-5384
Merke, D.P, Bornstein S. R., Avila N. and Chrousos G.P. (2002) Future Directions in the Study and Management of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. Ann. Internal Med. 136:320-334
Chrousos GPand Kino T (2005) Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic. Perspective, Science STKE. 304: pe48
Kino T and Chrousos GP (2007) Virus-mediated Modulation of the Host Endocrine Signaling Systems: Clinical Implications. Trends Endocrinol Metab. 18: 159-166         
Chrousos GP (2009) Stress and Disorders of the Stress System. Nat Rev Endocrinol. 5(7): 374-81

Contact Information

First Department of Pediatrics

Athens University Medical School

Children's Hospital Aghia Sophia

Thivon and Livadeias Streets

Athens, Attica, 115 27, Greece

Telephone:

+30-210-7794023

Fax Number:

+30-210-7759167

E-mail:

chrousog@mail.nih.gov; chrousge@med.uoa.gr

URL: https://biomarker.ksu.edu.sa/en/prof-george-chrousos